报告人简介：

Dr. Yang received his PhD in Polymer Chemistry and Physics in 2002 at Institute of Chemistry, The Chinese Academy of Science in Beijing. He is currently a full professor at the Department of Biomedical Engineering, The Pennsylvania State University. Dr. Yang has published 124 peer-reviewed journal articles and book chapter. He was a recipient of NSF CAREER Award (2010), Outstanding Young Faculty Award of College of Engineering at UTA (2011), and PSEAS Outstanding Research Award at Penn State (2018). Dr. Yang was elected to the Fellow of American Institute of Medical and Biological Engineering (AIMBE) in 2016 and the Fellow of National Academy of Inventors (NAI) in 2018.  Dr. Yang is the Co-Editors-in-Chief for journal “Bioactive Materials”, an Associate Editor for Journal “Frontiers in Biomaterials” and a standing member for NIH “Biomaterials and Biointerfaces” study section. Dr. Yang is the founding secretary and the current President for Chinese Association for Biomaterials (CAB). He has co-founded a biotechnology company, Aleo BME, Inc. and is also serving on the medical advisory board for Acuitive Technologies, Inc.

报告内容简介：

Citric acid presents inherent anti-bacterial, anti-clotting, angiogenic characteristics and modulates cellular energy levels leading to facilitated stem cell differentiation, which make citrate-based biomaterials ideal for a number of medical applications. We have attained a comprehensive new understanding of the citrate roles on osteo-phenotype progression and identified a new mechanism pertaining to the metabolic regulation of citrate to elevate cell energy status for bone formation, referred to as citrate metabonegenic regulation. This previously unexplored citrate metabonegenic regulation has allowed us to design new biomaterials to meet the dynamic biological, biochemical, and biophysical needs in bone regeneration. In this presentation, a methodology for the design of biomimetic citrate biomaterials and their applications in regenerative engineering, drug delivery, bioimaging and biosensing will be discussed with a focus on orthopedic engineering.

报告语言：英文