报告人介绍：JEAN-FRANÇOIS PAQUIN studied chemistryat Université Laval (Quebec City, Canada) where he graduated with a B.Sc.degree in 1999. In 2004, he received his Ph.D. degree at the University ofToronto (Canada). After a postdoctoral stay at the ETH Zürich (Switzerland), hewas appointed assistant professor in 2005 at Université Laval (Quebec City, Canada)as a Tier 2 Canada Research Chair in Organic and Medicinal Chemistry(2005-2010). In 2010, he was promoted to associate professor and his CanadaResearch Chair in Organic and Medicinal Chemistry renewed (2010-2015). He was promoted to Full Professor in2014.He has been awarded, in 2015, a Humboldt Research Fellowship for a6-month stay at the KIT in the group of Professor Anne S. Ulrich (Karlsruhe,Germany). In 2016, he received the Keith Fagnou Award from the Canadian Societyof Chemistry. His research interests include thedevelopment of novel methodologies for the synthesis of organofluorinecompounds and their applications for the preparation of bioactive fluorinatedcompounds or fluorinated biological probes. Jean-François has co-authored morethan one hundred publications in addition to fifteen book chapters. He haspresented more than one hundred invited lectures. Jean-François is a member of the Canadian Societyfor Chemistry (CSC) and the American Chemical Society (ACS). He has been amember-at-large on the executive committee of the Fluorine Chemistry Divisionof the ACS from 2013 to 2022. Finally, he was one of the co-hosts for theInternational Symposium on Fluorine Chemistry that took place in Quebec City inJuly 2023.
报告摘要：Since its discovery, the pentafluorosulfanylgroup (SF5) has been attracting its share of attention in organicchemistry. Considered as a “super CF3”, the SF5 group hasinteresting properties including, amongst others, a large dipole moment, a highlipophilicity and a strong electron-withdrawing capacity. These characteristicsmake it a substituent of choice in medicinal chemistry, agrochemistry andmaterial sciences. In that context, the development of novel synthetic methodsfor the preparation of pentafluorosulfanylated molecules in an importantobjective.
Thispresentation will describe some of our recent efforts towards the developmentof novel synthetic strategies for the preparation of SF5-containingmolecules.
