内容摘要：

Among the different types of dendrimers reported up to now phosphorus dendrimers that are dendrimers having one phosphorus atom at each branching point plays more and more an important role because of their intrinsic properties: easy regioselective functionalization of the core, within the structure and at the surface with the grafting of 2, 3, and even 4 different terminal groups on the outer shell , possibility to play with the hydrophilicity/hydrophobicity of the surface and of the core, the interior being hydrophobic, high thermal stability etc. Such properties allowed the use of these dendrimers in different fields ranging from biology, material science to catalysis. Regarding biology and medicinal chemistry water soluble phosphorus dendrimers display interesting behaviors. Ammonium-ended phosphorus dendrimers are efficient transfection agents, have a high antiprion activity, interact with amyloid monomers and consequently fibril formation are prevented, or affect Alzheimer’s(Aβ1-28) peptide and MAP-Tau protein aggregation. Polycationic phosphorus dendrimers having an optimized two-photon absorption chromophore as core allowed the imaging of the vascular network in the dorsal part of the rat olfactory bulb or was used for intra-cardiac injection in a living Xenopus tadpole allowing imaging of the blood vessels of the tail: no toxicity was detected for all these experiments.

主讲人简介：

Prof. Jean-Pierre Majoral obtained his Ph.D. degree in 1973 from the ‘Paul Sabatier University’ (Toulouse, France), 1973-1974 he joined the University of East-Anglia (UK) for a postdoctor. From 1972, he joined CNRS, where he is the Research Director now. He was the vice-director of Laboratory in 1998-2002 and director of the Department of “ Dendrimers, design and applications” in 2010-2012.  His research interests included design and properties of dendrimers from biology and medicinal chemistry to material sciences, and catalysis. Prof. Majoral is author of 595 publications, 45 patents and 5 books. The citation of 18 chapters of books is 13400 and his H index is 61.

讲座语言：英语