报告人简介：

Hongjun Wang，Associate Professor of Biomedical Engineering,Associate Professor of Chemistry, Associate Professor of Chemical Biology,Stevens Institute of Technology, New Jersey, US. His research interests includecomplex tissue formation, 3D in vitro tissue model, biomimetic materialsdesign, cell-materials interaction, nanomedicine, and regenerative medicine. Heobtained the 1st Ph.D. in Polymer Chemistry and Physics (Biomaterials) in 1998from Nankai University and University of Twente, Enschede, the Netherland, andthe 2nd Ph.D. in Biomedical Engineering (Tissue Engineering) in 2003 from HarvardMedical School and Massachusetts General Hospital, Boston. He was working asthe research fellow from 2003 to 2005. Out of 70 peer-reviewed journalpublications in addition to 5 pending patents, 2 issued patents, 7 provisionalpatents, 2 editorial papers, 8 book chapters, 1 book, over 100 conferenceabstracts & proceedings and invited talks since 1994.

报告摘要：

After decades of efforts from both academic andindustrial researchers, a great mass of knowledge and tremendous progress hasbeen made in tissue engineering, which has great potential in both regenerativemedicine and as an in vitro testing platform.However, in creation of large tissues/organs with multiplefunctionalities and hierarchical structures, several challenges, e.g.,vascularization and spatially controlled cell organization confound currenttissue engineering strategy.Recognitionof these challenges inspires our ongoing efforts in creating vasculature intissue-engineered substitutes and the development of bottom-up tissueengineering. The former enables the free exchange of nutrient and gas acrossthe large substitutes, and the latter allows straightforward manipulation ofthe spatial arrangement of multiple cell types and customization of the growthenvironment for individual cell type. Along with this endeavor, theconfiguration of a cell-friendly microenvironment is critical to guarantee thedesirable cell phenotype, leading to functional tissue formation. In thisregard, a biomimetic approach is taken in biomaterial design to maximallyrecapture the native cell-residing environment on a micro/nanoscale.

报告语言：双语