报告人简介：

Serge Mignani  

Formerly Head of Medicinal Chemistry Department and Scientific Director (Sanofi)

Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS, UMR 860, Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques, 45 rue des Saints Pères, 75006, Paris, France

CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal

报告内容简介：

The focus of this presentation will be to present and analyze the development of metallo-phosphorus dendrimers as new anticancer agents with original mechanism of action. Based on these anticancer activities, we developed original polycationic phosphorus dendrimers and dendrons as new anticancer agents. Interestingly, several of them, but with different chemical structure, showed antimycobacterial activities as first-in-class agents against tuberculosis. In addition, main structure-activity relationships will be also presented for the different chemical series related to biological activities.

报告语言：英语